Healthcare systems worldwide are experiencing a “new normal” as they face challenges that will characterise the next decade and beyond. The scale and complexity of these challenges is daunting. Tackling them cannot be done through doing the same things faster or ‘better’. We urgently require new models, approaches, paradigms and solutions. Some are already emerging in practice. Some are being envisioned. All need to be circulated, discussed and tested. Medicine and healthcare are changing, nothing will stay the same.Just some of the current and emerging challenges are: • Managing Complex Chronic Conditions• Doing More with Less Resources• Involving Patients as Co-Leaders of Their Care• Consolidating Multidisciplinary Work as Closer Collaboration amongst Professionals are Enhanced by New Knowledge and Technology• Digitalization and Virtualization in Health Care• Co-Production with Patients• Medical Tourism• Reshaping Skill Mix amongst Health Professions• New, Defensive Medicine - “Choosing Wisely”• Rethinking Clinical Governance• Managing Rapid Complex Change