Throughout Europe, an increasing proportion of GDP is being spent on healthcare, in order to cope with the rising challenges associated with aging populations, chronic diseases (both physical and mental) and public expectation. Based on this, one of the thematic priorities for the European Commission’s Third Health Programme 2014-2020 aims to ‘Contribute to innovative, efficient and sustainable health systems’ with eHealth and innovation playing a vital role to achieve this. This Forum Europe debate, taking place around the EU’s mid-term review on the second eHealth Action Plan, will include both digital innovation and horizontal, cross-sector perspectives, with a view to enabling a deeper, less siloed approach to healthcare thinking in Europe.