The epigenetic framework guides events like replication, repair and transcription, which in turn themselves leave an imprint on chromatin and chromosomal structure. Understanding how modulation of chromatin during replication and repair influence cell fate decisions in normal development and disease represents a major challenge. By bringing together leading scientists in chromatin, replication, and epigenetics, this conference aims to inspire discussions and new ideas on the interplay between chromosome organisation, epigenetic inheritance and genome duplication.