The Treaty of Lisbon marked a new step in the perennial debate over EU agencies, their powers and functioning, and their positioning within the EU organisational structure. Indeed, the reforms enacted by Lisbon inaugurate a new legal and institutional framework with a number of major practical implications for EU agencies. Against this backdrop, and going beyond purely legalistic considerations, this seminar has a pragmatic vocation as it will strive to describe the regulatory setting wherein the EU agencies work. It will also provide guidance on the fundamental procedures in which the agencies intervene, and interact with Member State officials and representatives of private commercial interests (scientific substantiation, handling highly technical-issues, risk assessment, rule-making procedures, etc.). Moreover, it will analyse the mechanisms for potential administrative and/or jurisdictional review of EU agencies’ acts, and discuss the legal standing of these agencies before the EU Courts. Last but not least, this seminar will contribute to the debate over EU agencies by addressing issues such as the agencies’ competences and the current calls to revise the so-called Meroni doctrine, which provides the benchmarks for delimiting their powers.