Transnational organised crime (TOC) refers to a fluid, self-perpetuating association of individuals and diversified industry engaged in illicit activities ranging from drug and human trafficking to piracy and money laundering, for the purpose of obtaining power, influence, monetary and/or commercial gains. The illicit activities of organised criminals threaten not only the interdependent commercial, transportation, communication and trans-actional systems that facilitate free trade and the movement of people throughout the global economy, but jeopardise governance structures, economic development, security, and supply chain integrity.This seminar will examine how the global criminal activities at its highest level of criminal sophistication are transforming the international system, upending the rules, creating new players, and reconfiguring power in international politics and economics, posing certain threats to the stability of nation states.More specifically, the seminar will analyse the various operating modes used by TOC to speculate in the weaknesses of public administrative practices, licit economies and markets. Special attention will be paid to the various forms of crime infiltration being utilized by criminal operators. It will examine and consider not only the criminal organizations and the markets within which they operate, but also the money that is generated, much of which goes into licit businesses and the global financial system.Finally, the European strategy for combating criminal infiltration in legal economy and public administration and the political harmonization among the various Member States for preventing TOC will be discussed.