The First International Conference on “Software and Emerging Technologies for Education, Culture, Entertaiment, and Commerce (SETECEC 2012): New Directions in Multimedia Mobile Computing, Social Networks, Human-Computer Interaction and Communicability” is a premier scientific meeting for discussing the latest advances in the emerging areas of computer sciences and technologies for education, cultural and natural heritage, virtual entertaiment and digital commerce, for instance.All contributions –papers, workshops, demos and doctoral consortium, should be of high quality, originality, clarity, significance and impact. In the current international conference it is demonstrated how with a correct integration among professionals of formal and factual sciences interesting research lines in the following subjects Computer Interfaces, Computer Arts and Creativity, Cultural Modeling, Education, Emerging Interactive Technologies, Hypermedia, Mobile Computing, Music and Digital Sounds, New Media, Quality Evaluation, Security, Social and Human Factors, Communicability, Software Engineering, and Software Scientific and other computational areas are solicited.