AGENDA

Inhalation Toxicology – Basics, Methods, Data Interpretation - Dr. Katharina Schwarz, Fraunhofer ITEM

• Introduction to Aerosols and Health-relevant Particle Size Fractions
• Deposition, Clearance, Solubility and Lung Toxicity
• Exposure Characterization: Simple to Refined Approaches
• Experimental Measurements: Primary Droplet Size Spectrum, Matured Aerosol
• Factors Influencing Aerosol Release from Spray Products
• Opportunities for Exposure Model Refinement: Experimental Data to Refine Models and Reduce Conservative Assum-ptions/Uncertainties
• Application of NOAEC Values in Risk Assessment
• Brief outlook: In-vitro and TTC Approaches in Safety Assessment

Aerosol Packaging and Regulatory Affairs - Dr. Uwe Rossow, C C R  GmbH & Co. KG 

• Legal Requirements on Packaging Safety
• Legal Requirement on Aerosol Labeling

Safety Assessment of Cosmetic Sprays and Powders – Exposure and Risk Evaluation - Dr. Gerlinde Pappa, Beiersdorf AG

• Demonstration of practical Aspects for the Safet Assessment of Cosmetic Spray Products, including Case Examples
• Parameters to consider in the Safety Assessment, Routes of Exposure, local and systemic Effects, Type I Allergy;
• Consideration of different Spray Technologies and their impact on the Safety Evaluation